Paper 2 H - SAMPLE SET 1 Q19
19) Wolfram’s Syndrome is a genetic disorder.
It is caused by a recessive allele (n).
In people with Wolfram’s syndrome, a protein does not function correctly.
(a) Explain how a change in an allele can stop a protein functioning correctly. [4]
(b) The diagram shows a pair of chromosomes from a person called Tim.
It is caused by a recessive allele (n).
In people with Wolfram’s syndrome, a protein does not function correctly.
(a) Explain how a change in an allele can stop a protein functioning correctly. [4]
(b) The diagram shows a pair of chromosomes from a person called Tim.
Fill in the table to show Tim’s genotype and phenotype.
Choose your answers from this list:
Choose your answers from this list:
- does not have Wolfram’s syndrome
- has Wolfram’s syndrome
- heterozygous
- homozygous dominant
- homozygous recessive
(c) (i) Meena is expecting a baby.
Tim is the father.
Complete this genetic diagram.
Tim is the father.
Complete this genetic diagram.
(ii) Wolfram’s syndrome can affect the pancreas.
Meena and Tim’s doctor tells them that there is a chance that their baby will have problems controlling their blood glucose level.
Explain why the doctor thinks this.
Use information from part (c) (i) and your biological knowledge. [4]
(Total for Question 19 = 12 marks)
Meena and Tim’s doctor tells them that there is a chance that their baby will have problems controlling their blood glucose level.
Explain why the doctor thinks this.
Use information from part (c) (i) and your biological knowledge. [4]
(Total for Question 19 = 12 marks)